NEJM This Week

Featuring articles on PCI before transcatheter aortic-valve implantation, treatments in patients with type 2 diabetes, in leprosy, in refractory adult ALL, and in ATTR cardiomyopathy; a review article on drug reaction with eosinophilia and systemic symptoms; a case report of a boy with recurrent fever; and Perspectives on an autopsy of a drug withdrawal, on clearing dense drug-patent thickets, on how a survey change sheds light on iatrogenic opioid use disorder and on being tethered.

Featuring articles on treatments for atrial fibrillation and stable coronary disease, for chronic hepatitis B, and for metastatic breast cancer; the 30-year cardiovascular disease risk in healthy women; and prenatal screening and detection of maternal cancer; a review article on sepsis and septic shock; a case report of a woman with headache, fever, and respiratory failure; and Perspectives on Medicare’s bundled-payment programs, on handcuffs and unexpected deaths, on the Marburg outbreak in Rwanda, and on the care that saved one parent.

Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day.

Featuring articles on a nationwide couple-based genetic screening; adjunctive embolization for subdural hematoma; a late-liver-stage attenuated malaria vaccine; and climate change, floods, and human health; a review article on Candida auris infections; a case report of a girl with abdominal pain; and Perspectives on Medicare’s first round of drug-price negotiation; on invisible deaths; on minding the sentinel; and on Saint Didacus, fetal death, and dual loyalty.